Interpretation Principles

Research / Interpretation Principles
Biomarker vs Lifespan Calibration

Interpretation Principles

Scientific integrity depends not only on reporting findings, but on defining their boundaries. The Canine Geronutrition Initiative emphasizes careful interpretation of biomarker-based research within appropriate context.

The following principles guide all content presented on this platform.

1. Biomarkers Are Not Lifespan

Changes in biomarkers reflect measurable biological parameters within defined study conditions.

They do not independently demonstrate lifespan extension, disease prevention, or reversal of aging.

2. Association Does Not Establish Causation

Observed relationships in controlled studies indicate statistical association.

They do not confirm direct causality unless supported by mechanistic and longitudinal validation.

3. Controlled Environments Differ from Real-World Settings

Feeding trials and laboratory assessments occur under standardized conditions.

Outcomes may differ in household environments where genetic variability, activity level, and environmental factors vary.

4. Nutrition Is Not Medical Therapy

Nutritional strategies may support physiological processes.

They do not replace veterinary care, pharmaceutical treatment, or disease management protocols.

5. Context Defines Meaning

Scientific findings must be interpreted within:

  • Study design parameters
  • Duration
  • Sample size
  • Endpoint selection
  • Statistical framework

  • Extrapolation beyond these parameters risks misinterpretation.

6. Responsible Communication

The Initiative is committed to:

  • Evidence-based discussion
  • Transparent acknowledgment of limitations
  • Clear differentiation between research and application

  • Scientific progress depends on both curiosity and restraint.