Advancing Nutritional Science for Healthy Aging in Dog

Exploring cellular maintenance, nucleotide metabolism, and biomarker research in companion animals.

Welcome to the Canine Geronutrition Initiative

Explore our commitment to enhancing the health of companion animals through innovative nutritional research focused on aging. Join us in fostering a healthier, longer life for our beloved dogs.

Ongoing Research

Our commitment to continuous research ensures we stay at the forefront of canine geronutrition advancements.

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Our commitment to continuous research ensures we stay at the forefront.

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Why Healthy Aging Matters

Aging in dogs is characterized by gradual cellular stress, reduced regenerative efficiency, and increased metabolic demand. Understanding the biological basis of aging allows nutritional science to contribute meaningfully to long-term vitality.

Emerging aging biomarkers in dogs

1. Telomere Length

Telomeres shorten as cells divide and age. Shorter telomeres are associated with cellular replicative exhaustion and increased disease risk.

2. DNA Methylation Age

Also called "Epigenetic Clock", DNA methylation patterns change predictably with age. Epigenetic clocks estimate biological age and may detect accelerated or slowed aging.

3. Cellular Senescence Markers

p16^INK4a Expression

p21 Expression

SA-β-gal Activity
SASP Cytokines

4. Inflammatory Marker

C-Reactive Protein (CRP)

Interleukin-6 (IL-6)

Tumor Necrosis Factor-α (TNF-α)
MCP-1

5. Growth & Hormonal Markers

Insulin-Like Growth Factor-1 (IGF-1)

6. Metabolic Markers

Fasting Glucose
Insulin Sensitivity
Lipid Profile
AMPK Activity

mTOR Signaling

7. Mitochondrial Markers

mtDNA Copy Number
Reactive Oxygen Species (ROS)
ATP Production

8. Stem Cell Markers

Bone Merrow Density
Circulating Progenitor Cells

9. NAD⁺ Levels

NAD⁺ Concentration

10. Proteomic Aging Signatures

Plasma Proteomic Age

11. Functional Aging Markers

Gait Speed
Muscle Mass (Lean Body Mass)
Activity Levels
Cognitive Function Scores

12. Composite Aging Index

Multimodal Aging Score Combines molecular, metabolic, and functional markers. Provides a more accurate estimate of biological aging than any single biomarker.

CGI Framework Diagram

Conceptual Framework in Canine Geronutrition Research
Mechanistic Context → Measurement → Responsible Interpretation

AGING MECHANISMS

- Genomic Instability

- Telomere Dynamics

- Mitochondrial Function

- Proteostasis Immune Modulation

Multifactorial and genetically influenced processes

CELLULAR PROCESSES

- Cellular Replication

- Metabolic Coordination

- Redox Balance

- Immune Cell Turnover

- Tissue Maintenance

Dynamic processes occurring across high-turnover tissues

BIOMARKERS

- Telomere Length Metrics

- Inflammatory Indices

- Oxidative Stress Markers

- Metabolic Parameters

Context-dependent and method-sensitive

INTERPRETATION BOUNDARIES

Association within defined study context
Biological signal interpretation
Comparative analysis

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✘ Lifespan extension claim

✘ Disease treatment inference

✘ Clinical outcome extrapolation

Our Approach

We distinguish between:

Pharmaceutical pathway modulation

Nutritional substrate support

Nutritional strategies are not intended to replace veterinary therapies, but may contribute foundational support within daily diets.

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